At Laser & Cosmetic Surgery Specialists in Newburgh, NY, Selphyl PRFM and Selphyller Gel treatments are performed by double board-certified facial plastic surgeon Ran Y. Rubinstein, MD. Patients from Orange County and throughout New York—including Middletown, Goshen, Cornwall, New Windsor, Monroe, Warwick, Poughkeepsie, Fishkill, Kingston, and New Paltz—visit the practice for advanced facial plastic surgery and non-surgical facial rejuvenation treatments.
What Is PRF EZ Gel?
PRF EZ Gel is an autologous (from your own body) injectable gel created from a combination of:
- A platelet-rich fibrin blood concentrate (PRF)
- A plasma-derived protein component created by heating a portion of the patient’s plasma to form a gel
Selphyl PRFM, the treatment Dr. Rubinstein prefers and offers at our practice, is built on the same regenerative principles. In the Selphyl PRFM system, the fibrin component forms a scaffold that allows growth factors and cytokines to be released more gradually compared with traditional PRP approaches. Selphyller Gel is the autologous gel created from Selphyl PRFM.
Because these gels are derived from your own blood, the material is biocompatible and is often chosen by patients who want a more natural approach to injectable rejuvenation.

THE PROCEDURE
What Concerns Can PRF EZ Gel and Selphyl PRFM Treat?
Autologous treatments of this kind, including the Selphyl PRFM treatments offered at our practice, are commonly used for concerns related to early facial aging and skin quality changes, including:
- Under-eye hollowing and a tired appearance
- Fine lines and crepey texture in delicate areas
- Mild contour irregularities where subtle support is helpful
- Dull skin tone and uneven texture
- Acne scarring or minor scar texture concerns (in appropriate cases)
This is not a substitute for surgical lifting when laxity is significant, and it is not designed for large-volume augmentation. Dr. Rubinstein helps patients choose the most appropriate option based on anatomy and goals.

Where Can Selphyl PRFM Be Used?
Selphyl PRFM and Selphyller Gel are typically used in areas where patients want improvement in skin quality and subtle soft-tissue support, especially in regions where a conservative, biologic approach is preferred.
Commonly treated areas may include:
- Under-eye region (when appropriate for the patient’s anatomy)
- Cheeks/midface (select cases)
- Areas of fine textural change and early lines
- Targeted scar or texture irregularities
Because facial anatomy varies significantly, Dr. Rubinstein’s treatment plan is customized. Some patients may be better served by dermal fillers, biostimulants, laser resurfacing, microneedling, or surgery.

How PRF EZ Gel and Selphyl PRFM Work
Both PRF EZ Gel and Selphyl PRFM are based on the concept of using your own blood components to support tissue quality.
PRF and PRFM rely on the formation of a fibrin scaffold, which allows for a slower release of growth factors and cytokines over time. EZ Gel and Selphyller Gel each add a protocol step that uses controlled heating to form a protein-based injectable gel.
Clinically, this approach can provide subtle, natural-looking support in targeted areas while encouraging gradual improvement over time.
How PRFM Fits Into Facial Rejuvenation
Facial rejuvenation often involves a combination of treatments designed to address different aspects of aging. Some injectable treatments focus primarily on restoring lost volume, while others aim to improve skin quality and stimulate natural tissue response.
Selphyl PRFM and treatments like PRF EZ Gel are considered regenerative because they are created from components of the patient’s own blood. Rather than placing a synthetic filler beneath the skin, the gel is prepared using platelet-rich fibrin and plasma proteins. The goal is to provide subtle structural support while encouraging gradual improvement in skin quality.
Other injectable treatments may be recommended when more immediate structural volume or contour correction is needed. Hyaluronic acid fillers, for example, are often used to restore volume in areas such as the cheeks or lips, while biostimulatory injectables are sometimes chosen to promote collagen production over time.
During consultation, Dr. Rubinstein evaluates the patient’s facial anatomy and skin quality to determine which approach—or combination of treatments—will best achieve natural-looking facial rejuvenation.

Consultation and Personalized Treatment Planning
Every Selphyl PRFM treatment begins with a consultation. Dr. Rubinstein evaluates:
- Facial shape and support
- Skin thickness and elasticity
- Under-eye anatomy and midface volume
- Areas where biologic support may be helpful
- Whether another treatment is likely to be a better option
Because this treatment is used in nuanced facial areas, careful patient selection and precise technique matter. Unlike hyaluronic acid fillers, autologous treatments such as Selphyl PRFM and Selphyller Gel are not reversible — making it especially important to seek treatment from an experienced, advanced injector with an in-depth understanding of facial anatomy. Dr. Rubinstein’s surgical background and extensive experience with injectable treatments make him well positioned to achieve precise, natural-looking outcomes with regenerative treatments of this kind.
Who Is a Good Candidate for Selphyl PRFM?
Selphyl PRFM and Selphyller Gel may be a good fit for patients who:
- Want a natural, autologous approach to injectable rejuvenation
- Have early signs of aging such as under-eye hollowing or skin texture concerns
- Prefer gradual improvement
- Want to avoid synthetic dermal fillers (when appropriate)
Patients who need substantial lifting or major volume replacement may be better candidates for surgery or other injectable strategies.
Selphyl PRFM & Selphyller Gel: An Advanced Approach to PRF Treatment
At Laser & Cosmetic Surgery Specialists, Dr. Rubinstein prefers Selphyl PRFM over PRF EZ Gel. While both build on the regenerative principles of platelet-rich fibrin, Selphyl PRFM represents a more refined approach to this category of therapy. Selphyl PRFM converts PRP into a structured fibrin matrix using a proprietary closed system, localizing growth factors at the treatment site for a more sustained release over time compared with standard PRF approaches.
Selphyller Gel takes this further by converting the PRFM into a viscous, gel-like consistency through controlled thermal processing — creating a true autologous filler derived entirely from the patient’s own blood. The slow release of growth factors supports collagen production, new blood vessel formation, and gradual volume restoration, while the gel’s thicker consistency provides more immediate soft-tissue support than standard EZ Gel. Patients interested in how Selphyller Gel compares to standard EZ Gel can find a detailed comparison in the FAQ section below.
Preparing for Your PRFM Treatment
Because the quality of the PRF and PRFM sample depends directly on the quality of the blood draw, a few simple preparation steps can meaningfully improve your results. For several days leading up to your appointment, staying well hydrated supports better platelet quality and makes the collection process smoother. It is also advisable to avoid alcohol, NSAIDs such as ibuprofen or aspirin, blood thinners, and antibiotics for several days prior to treatment, as these can affect platelet count and function. Dr. Rubinstein’s team will provide specific pre-treatment instructions during your consultation.

The Selphyl PRFM and Selphyller Gel Treatment Process
A typical appointment includes:
- Blood draw (similar to routine lab work)
- Centrifugation to isolate PRP, which is converted to Selphyl PRFM with the addition of a small amount of calcium chloride
- A controlled heating step to create the gel material
- Injection into targeted areas based on the treatment plan
Treatment time varies by the number of areas treated but is commonly completed in a single office visit.
Recovery After PRFM Treatment
Most patients have minimal downtime. Temporary effects may include:
- Mild swelling
- Minor bruising
- Tenderness at injection sites
These typically resolve over several days. Patients are usually able to return to normal routines quickly, though timing can vary based on injection depth and the treatment area.

Why Choose Dr. Ran Y. Rubinstein for PRFM Treatment?
Ran Y. Rubinstein, MD is a double board-certified facial plastic surgeon. His approach to injectables emphasizes precision, facial harmony, and natural-looking outcomes.
At Laser & Cosmetic Surgery Specialists in Newburgh, patients benefit from a physician-led practice offering both surgical facial procedures and non-surgical facial rejuvenation options, allowing treatment planning to stay focused on what best fits the patient—not a one-size approach.
Frequently Asked Questions About PRF EZ Gel and Selphyl PRFM
Schedule a Selphyl PRFM Consultation in Newburgh, NY
If you have been researching PRF EZ Gel, a consultation with Dr. Ran Y. Rubinstein in Newburgh, NY can help you understand how Selphyl PRFM and Selphyller Gel compare and whether they are the right fit for your goals. A personalized plan can help address volume changes, skin quality concerns, and overall facial balance with a treatment approach that fits your anatomy and preferences.

